Portal Streamlines Multiplexed Cell Engineering

Portal Unlocks Cell Engineering Capabilities

Gene Editing

Deletion, correction, insertions across primary cells

Multiplexed Modifications

Simultaneous delivery of multiple RNA and CRISPR molecules for multi engineered cells

Immune Cell Therapies

Engineering adaptive and innate immune responses across oncology, infectious disease and autoimmunity

iPSCs & Regenerative Medicine

Engineered tissues, disease modeling, drug screening in patient cells

Portal is Developing a Universal Cell Engineering Solution

Portal’s proprietary membrane technology uses mechanical disruption and enables massive parallelization

Portal mechanoporation yields robust multiplex delivery in Unstimulated T Cells

Activated NK cells Boost

50+ partners worldwide, including

Products

Gateway

Research Scale

Benchtop instrument for discovery research

0.5-10M cells per run

50-200 µl volume range

compact benchtop unit that fits in any hood

Available now

Galaxy-i

High-Throughput Screening

High throughput scale instrument for screening applications with multi well plates.

96/384-well plate compatibility

Integrate with existing automation

Ideal for DEL, PROTAC, crispr screening

Available now

Millibooster

Clinical Manufacturing

GMP-ready clinical production system

1 billion+ cells/minute throughput

Attach to existing equipment via tube-weld or luer lock connection

2-100mL volume range

Available Now

Pick your cell and cargo to see the data

All Cells

All Cargos

Publication · 2022 · FRONTIERS IN IMMUNOLOGY

Engineered Red Blood Cells (Activating Antigen Carriers) Drive Potent T Cell Responses and Tumor Regression in Mice

Katarina Blagovic, Carolyne K. Smith, Amritha Ramakrishnan, Lindsay Moore, David R. Soto, Zachary Thompson, Adam P. Stockmann, Sonia Kruszelnicki, Akshi Thakkar, Jason Murray, Sebastian Torres, Bersabel Wondimagegnhu, Roslyn Yi, Maisam Dadgar, Abdul M. Paracha, Claire Page, Louise Clear, Omer A. Chaudhry, Melissa Myint, Devin T. Bridgen, Jonathan B. Gilbert, Katherine J. Seidl, Armon Sharei, Scott Loughhead, Howard Bernstein, and Defne Yarar

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Publication · 2022 · ESMO IMMUNO-ONCOLOGY AND TECHNOLOGY

Cell Squeeze®: Driving more effective CD8 T cell activation through cytosolic antigen delivery

Jong Chul Park, Howard Bernstein, Scott Loughhead, Ricardo Zwirtes, Julia

Jennings, Valeria Nicolini, Christian Klein, Laura Codarri Deak, Pablo Umana,

Christine Trumpfheller, Armon Sharei

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Publication · 2022 · FRONTIERS IN IMMUNOLOGY

Engineered RBCs Encapsulating Antigen Induce Multi-Modal Antigen-Specific Tolerance and Protect Against Type 1 Diabetes

Colin J. Raposo, Judith D. Cserny, Gloria Serena, Jonathan N. Chow, Patricia Cho, Hanyang Liu, David Kotler, Armon Sharei, Howard Bernstein, and Shinu John

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Publication · 2022 · JOURNAL OF IMMUNOLOGY

Microfluidic Squeezing Enables MHC Class I Antigen Presentation by Diverse Immune Cells to Elicit CD8+ T Cell Responses with Antitumor Activity

Matthew G. Booty, Kelan A. Hlavaty, Adam Stockmann, Howard Bernstein, Armon Sharei, Scott M. Loughhead, Hendrik Knoetgen, Christine Trumpfheller, Pablo Umaña, Ulrich H. von Andrian, Klavs F. Jensen, Robert Langer, Jacques, Eritza Chong, Lucas Pomerance, John T. Gonzalez, Shirley Mao, Megan Heimann, LeeAnn Talarico, Miye K. Jonathan Chow, Tarek Abdeljawad, Harry An, Sophia Liu, Vicente-Suarez, Defne Yarar, Melissa Myint, Amy Merino, Olivia Pryor, Kelly Volk, Katarina Blagovic, Ildefonso, Disha Subramanya, Anita Venkitaraman, Christian Yee, Emrah Ilker Ozay, Carolyne Smith, Lina Tian, Edylle How

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