Don't Transfect, Just Deliver!

Multi cargo. High viability. Better delivery.

Get Boosting with The Gateway™ System

What’s included

Gateway™ System

6 Months White Glove Technical Support

Booster™ Subscription

Cell Engineering Kits

Validated biological workflows — a one stop shop.

Every kit includes: Portal-sourced RNA · Optimized protocols · MicroBooster™ cartridges · Suggested readouts · Reagents

CELL THERAPY

T Cell Functional Enhancement

Best suited for: Human T cells (activated or unstimulated), PBMCs
Available enhancements: mbIL2, mbIL12, Perforin, Gzmb, B2M and TCR knockouts
Measure endogenous intracellular proteins in live cells
Use cases: Cytokine armoring, gene KO, persistence enhancement

STEM CELL BIOLOGY

iPSC Generation

Best suited for: PBMCs & fibroblasts
Available enhancements: Oct4, Sox2, Klf4, cMyc RNA
Best suited for: Reprogramming, disease modeling

IMMUNOLOGY

APC Enhancement

Best suited for: PBMCs, dendritic cells
Available enhancements: mbIL2, mbIL12, CD86, custom antigen RNA
Best suited for: Immune activation, DC engineering, vaccine research

Stem cell biology

HSC Enhancement

Best suited for: Hematopoietic stem cells
Available enhancements: CXCR4, BCL2
Best suited for: Engraftment, survival, stemness preservation

NEUROSCIENCE

Neuronal Differentiation

Best suited for: iPSC-derived neurons, neural progenitors
Available enhancements: NGN2, ASCL1, LMX1A, FOXA2, NURR1, ASOs
Best suited for: Neuronal differentiation, disease modeling, Parkinson's/ALS

Drug Discovery Kits

Portal — enabling live-cell assays, target engagement, and compound profiling.

Kits include: Optimized protocols · Portal reagents · Delivery cartridges · Suggested readouts

Impermeable Candidate Validation in Live Cells

Solves: Permeability engineering as a prerequisite for testing cellular activity
Cargo: Your impermeable drug candidate
Validate and test your candidates in live cells, regardless of permeability
e.g. small molecules, macrocycles, peptides

Live-Cell Protein Detection

Solves: Live-cell context lost to lysis, and target labeling that requires cell engineering.
Cargo: Intracellular antibodies (primary & secondary)
Measure endogenous intracellular proteins in live cells
e.g. p-BTK, p-ERK, p-AKT, p-STAT3, p-MET Compatible with LgBiT/HgBiT reagents

Live-Cell Target Engagement

Solves: Live-cell context lost to lysis and detergents, and the need to create cell-permeable tracers
Cargoes: Your tracers (e.g. NanoBRET) and compounds
Enables live-cell target engagement without lysis; supports impermeable tracers
e.g. kinase inhibitor profiling, degrader engagement

Controllable Surface Antigen Expression

Solves: Fixed, hard-to-modulate surface antigen expression in cell lines
Cargo: Custom antigen/receptor RNA — single or combinations
Express any antigen on any cell in hours
e.g. CD19+CD3, BCMA+CD3, HER2+CD3

Direct-to-Assay

Solves: The stable-line bottleneck: infeasible in primary cells, slow and laborious elsewhere
Cargo: Custom RNA encoding tagged POI
Run NanoBRET or LgBiT/HgBiT without stable lines
e.g. VHL-NanoLuc, HgBiT-tagged POI, HA-tagged POI

Intracellular DEL Screening

Solves: DEL screens can't be done in live human cells
Cargo: Your DEL library
Screen intracellular targets with no library bias
e.g. iPSCs, HeLa, PBMCs — any cell type

Boost cells

Research Scale Mechanical Delivery

Boost Cells Fast

Boost at over 10M cells/s

Buffer Flexibility

Compatible with many common media

Future Proof

Subscription includes free hardware upgrades to future models

Booster™ Cartridge

Delivery solutions available for T cells, B cells, NK cells, Monocytes, iPSCs and HSCs. Want another cell type? Just ask!

Proprietary Membrane

Optimized for delivery and cell viability

Compatible across cell concentration and buffers

Learn to Boost!

Broad Compatibility

Portal’s platform supports delivery with a diverse matrix of cell types and cargoes.

mRNA, siRNA, saRNA

Proteins & Peptides

CRISPR RNPs

Small Molecules

Carbon Nanotubes

Polymers

Nanoparticles

Antibodies

Viruses

Labeling Molecules

PBMCs

B cells

NK cells

iPSCs

RBCs

T cells

Monocytes

HSCs

HeLa

HEK

mRNA, siRNA, saRNA

Proteins & Peptides

CRISPR RNPs

Small Molecules

Carbon Nanotubes

Polymers

Nanoparticles

Antibodies

Viruses

Labeling Molecules

PBMCs

B cells

NK cells

iPSCs

RBCs

T cells

Monocytes

HSCs

HeLa

HEK

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The Future of Cell Engineering is Here